Lateral hypothalamic circuits for feeding and reward
In experiments conducted over 60 years ago, the lateral hypothalamic area (LHA) was
identified as a critical neuroanatomical substrate for motivated behavior. Electrical …
identified as a critical neuroanatomical substrate for motivated behavior. Electrical …
[HTML][HTML] Obesity: an immunometabolic perspective
Obesity, characterized by chronic activation of inflammatory pathways, is a critical factor
contributing to insulin resistance (IR) and type 2 diabetes (T2D). Free fatty acids (FFAs) are …
contributing to insulin resistance (IR) and type 2 diabetes (T2D). Free fatty acids (FFAs) are …
Ventral tegmental area orexin 1 receptors promote palatable food intake and oppose postingestive negative feedback
SJ Terrill, KM Hyde, KE Kay… - American Journal …, 2016 - journals.physiology.org
Hypothalamic orexin neurons project to numerous brain areas, including the ventral
tegmental area (VTA), which is involved in motivation and food-seeking behavior. Here we …
tegmental area (VTA), which is involved in motivation and food-seeking behavior. Here we …
Sleep control, GPCRs, and glucose metabolism
H Tsuneki, T Sasaoka, T Sakurai - Trends in Endocrinology & Metabolism, 2016 - cell.com
Modern lifestyles prolong daily activities into the nighttime, disrupting circadian rhythms,
which may cause sleep disturbances. Sleep disturbances have been implicated in the …
which may cause sleep disturbances. Sleep disturbances have been implicated in the …
Orexins A and B stimulate proliferation and differentiation of porcine preadipocytes
T Wojciechowicz, M Skrzypski… - Experimental …, 2016 - journals.sagepub.com
Orexin A (OXA) and B (OXB) are neuropeptides which regulate appetite, energy
expenditure, and arousal via G-protein coupled receptors termed as OXR1 and OXR2. The …
expenditure, and arousal via G-protein coupled receptors termed as OXR1 and OXR2. The …
Lateral hypothalamic area orexin-A influence the firing activity of gastric distension-sensitive neurons and gastric motility in rats
H Hao, X Luan, F Guo, X Sun, Y Gong, L Xu - Neuropeptides, 2016 - Elsevier
The orexins system consists of two G-protein coupled receptors (the orexin-1 and the orexin-
2 receptor) and two neuropeptides, orexin-A and orexin-B. Orexin-A is an excitatory …
2 receptor) and two neuropeptides, orexin-A and orexin-B. Orexin-A is an excitatory …