Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

Q Chen, W Yan, E Duan - Nature Reviews Genetics, 2016 - nature.com
Once deemed heretical, emerging evidence now supports the notion that the inheritance of
acquired characteristics can occur through ancestral exposures or experiences and that …

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification

LM Iyer, D Zhang, L Aravind - Bioessays, 2016 - Wiley Online Library
While N6‐methyladenosine (m6A) is a well‐known epigenetic modification in bacterial DNA,
it remained largely unstudied in eukaryotes. Recent studies have brought to fore its potential …

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

B Delatte, F Wang, LV Ngoc, E Collignon, E Bonvin… - Science, 2016 - science.org
Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that
hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in …

NSUN3 and ABH1 modify the wobble position of mt‐tRNAMet to expand codon recognition in mitochondrial translation

S Haag, KE Sloan, N Ranjan, AS Warda… - The EMBO …, 2016 - embopress.org
Mitochondrial gene expression uses a non‐universal genetic code in mammals. Besides
reading the conventional AUG codon, mitochondrial (mt‐) tRNAM et mediates incorporation …

The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

D Kao, AG Lai, E Stamataki, S Rosic, N Konstantinides… - elife, 2016 - elifesciences.org
The amphipod crustacean Parhyale hawaiensis is a blossoming model system for studies of
developmental mechanisms and more recently regeneration. We have sequenced the …

Post-transcriptional modifications in development and stem cells

M Frye, S Blanco - Development, 2016 - journals.biologists.com
Cells adapt to their environment by linking external stimuli to an intricate network of
transcriptional, post-transcriptional and translational processes. Among these, mechanisms …

Epigenomics in marine fishes

DCH Metzger, PM Schulte - Marine Genomics, 2016 - Elsevier
Epigenetic mechanisms are an underappreciated and often ignored component of an
organism's response to environmental change and may underlie many types of phenotypic …

The emerging epitranscriptomics of long noncoding RNAs

A Shafik, U Schumann, M Evers, T Sibbritt… - Biochimica et Biophysica …, 2016 - Elsevier
The pervasive transcription of genomes into long noncoding RNAs has been amply
demonstrated in recent years and garnered much attention. Similarly, emerging …

Inhibitors of DNA methylation, histone deacetylation, and histone demethylation: a perfect combination for cancer therapy

CA Zahnow, M Topper, M Stone… - Advances in cancer …, 2016 - Elsevier
Epigenetic silencing and inappropriate activation of gene expression are frequent events
during the initiation and progression of cancer. These events involve a complex interplay …

DNA methyltransferases exhibit dynamic expression during spermatogenesis

F Uysal, G Akkoyunlu, S Ozturk - Reproductive biomedicine online, 2016 - Elsevier
DNA methylation is one of the epigenetic marks and plays critically important functions
during spermatogenesis in mammals. DNA methylation is catalysed by DNA …