Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
[HTML][HTML] IDH mutations in cancer and progress toward development of targeted therapeutics
L Dang, K Yen, EC Attar - Annals of Oncology, 2016 - Elsevier
ABSTRACT Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes,
converting isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 mutations have been …
converting isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 mutations have been …
CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009–2013
Background CBTRUS is a unique professional research organization that focuses
exclusively on providing high quality statistical data on the population-based incidence of …
exclusively on providing high quality statistical data on the population-based incidence of …
TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data
Abstract The Cancer Genome Atlas (TCGA) research network has made public a large
collection of clinical and molecular phenotypes of more than 10 000 tumor patients across …
collection of clinical and molecular phenotypes of more than 10 000 tumor patients across …
Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of
somatic glioma driving alterations and suboptimal disease classification. We defined the …
somatic glioma driving alterations and suboptimal disease classification. We defined the …
Insulator dysfunction and oncogene activation in IDH mutant gliomas
Gain-of-function IDH mutations are initiating events that define major clinical and prognostic
classes of gliomas,. Mutant IDH protein produces a new onco-metabolite, 2 …
classes of gliomas,. Mutant IDH protein produces a new onco-metabolite, 2 …
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
Comprehensive molecular characterization of papillary renal-cell carcinoma
Cancer Genome Atlas Research … - New England Journal of …, 2016 - Mass Medical Soc
Background Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell
carcinomas, is a heterogeneous disease that consists of various types of renal cancer …
carcinomas, is a heterogeneous disease that consists of various types of renal cancer …
Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression
Increased overall survival for patients with glioma brain tumours is associated with mutations
in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a …
in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a …
Macrophage ontogeny underlies differences in tumor-specific education in brain malignancies
Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident
macrophages, with unique transcriptional profiles endowing the cells with tissue-specific …
macrophages, with unique transcriptional profiles endowing the cells with tissue-specific …