Functional characterization of AMP-activated protein kinase signaling in tumorigenesis
AMP-activated protein kinase (AMPK) is a ubiquitously expressed metabolic sensor among
various species. Specifically, cellular AMPK is phosphorylated and activated under certain …
various species. Specifically, cellular AMPK is phosphorylated and activated under certain …
Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress
JH Yang, SC Kim, KM Kim, CH Jang, SS Cho… - European journal of …, 2016 - Elsevier
Hepatic fibrosis is considered integral to the progression of chronic liver diseases, leading to
the development of cirrhosis and hepatocellular carcinoma. Activation of hepatic stellate …
the development of cirrhosis and hepatocellular carcinoma. Activation of hepatic stellate …
Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model
SI Chung, H Moon, HL Ju, KJ Cho, KH Han, JW Eun… - Journal of …, 2016 - Elsevier
Background & Aims Liver fibrosis is an increasing health concern worldwide and a major
risk factor for hepatocellular carcinoma (HCC). Although the involvement of Hedgehog …
risk factor for hepatocellular carcinoma (HCC). Although the involvement of Hedgehog …
Epithelial transforming growth factor-β signaling does not contribute to liver fibrosis but protects mice from cholangiocarcinoma
X Mu, JP Pradere, S Affò, DH Dapito, R Friedman… - Gastroenterology, 2016 - Elsevier
Background & Aims Transforming growth factor-β (TGFβ) exerts key functions in fibrogenic
cells, promoting fibrosis development in the liver and other organs. In contrast, the functions …
cells, promoting fibrosis development in the liver and other organs. In contrast, the functions …
TAK1 regulates hepatic lipid homeostasis through SREBP
S Morioka, K Sai, E Omori, Y Ikeda, K Matsumoto… - Oncogene, 2016 - nature.com
Sterol-regulatory element-binding proteins (SREBPs) are key transcription factors regulating
cholesterol and fatty acid biosynthesis. SREBP activity is tightly regulated to maintain lipid …
cholesterol and fatty acid biosynthesis. SREBP activity is tightly regulated to maintain lipid …
Post‑translational modification of CREB‑1 decreases collagen I expression by inhibiting the TGF‑β1 signaling pathway in rat hepatic stellate cells
X Deng, L Deng, P Wang… - Molecular Medicine …, 2016 - spandidos-publications.com
Liver fibrosis is a reversible wound‑healing response to liver damage. Following liver injury,
activated hepatic stellate cells (HSCs) cause excessive deposition of collagen and other …
activated hepatic stellate cells (HSCs) cause excessive deposition of collagen and other …
Protective effects of S-adenosylmethionine against CCl4- and ethanol-induced experimental hepatic fibrosis
F Zhang, JX Gu, XP Zou, YZ Zhuge - Molecular Biology, 2016 - Springer
In this study the effects of S-adenosylmethionine (SAM) on experimental hepatic fibrotic rats
induced by carbon tetrachloride (CCl 4) and ethanol and the relevant potential mechanisms …
induced by carbon tetrachloride (CCl 4) and ethanol and the relevant potential mechanisms …
乙肝相关性肝细胞肝癌代谢重编程机制探讨
罗昊翔 - 基因组学与应用生物学, 2016 - biopublisher.cn
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[HTML][HTML] 肝硬化肝脏部分切除术后肝再生的研究进展
石文征， 阎凯， 宋京海 - 世界华人消化杂志, 2016 - wjgnet.com
肝脏是具有强大再生能力的器官, 其再生机制十分复杂. 肝再生是一个受多种调控因子参与的
高度协调的过程, 同时再生的过程中受多种因素影响. 肝硬化是影响肝再生的一个重要因素 …
高度协调的过程, 同时再生的过程中受多种因素影响. 肝硬化是影响肝再生的一个重要因素 …