New therapeutic approaches for the treatment of obesity | Science Translational Medicine
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Genetics plays an important role in determining the susceptibility of an individual to develop
a disease. Complex, multi factorial diseases of modern day (diabetes, cardiovascular …

The" thrifty gene hypothesis" suggests genetic susceptibility to obesity arises because of
positive selection for alleles that favored fat deposition and survival during famines. We used …

To explore the logic of evolutionary explanations of obesity we modelled food consumption
in an animal that minimizes mortality (starvation plus predation) by switching between …

Obesity is a well-established risk factor for various health conditions. There are multiple
explanations that shed light on the modern obesity epidemic, and long-term studies are …

Background The reward deficiency syndrome hypothesis posits that genes are responsible
for reward dependence and related behaviors. There is evidence that both bulimia and …

Obesity and its metabolic complications have emerged as the epidemic of the new millennia.
The use of obese rodent models continues to be a productive component of efforts to …

Spontaneous physical activity (SPA) represents an important component of daily energy
expenditures in animals and humans. Intra-specific variation in SPA may be related to the …

In sociocultural discussions of eating, metabolism is often either absent or framed as a dull
biological hinterland to the interesting business of taste, meaning, ideology and so on. This …

Highlights•The mesoaccumbens-striato-hypothalamus system integrates signals from
central and peripheral regulators of energy status and food reward.•Palatable energy dense …