For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

We argue that the global burden of mental illness is underestimated and examine the
reasons for under-estimation to identify five main causes: overlap between psychiatric and …

Background The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides
an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden …

Background The pandemic of physical inactivity is associated with a range of chronic
diseases and early deaths. Despite the well documented disease burden, the economic …

Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs)
provide summary measures of health across geographies and time that can inform …

Background In transitioning from the Millennium Development Goal to the Sustainable
Development Goal era, it is imperative to comprehensively assess progress toward reducing …

Background One of the global targets for non-communicable diseases is to halt, by 2025, the
rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to …

Background With recent improvements in vaccines and treatments against viral hepatitis, an
improved understanding of the burden of viral hepatitis is needed to inform global …

Background The contribution of modifiable risk factors to the increasing global and regional
burden of stroke is unclear, but knowledge about this contribution is crucial for informing …

Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to
behavioural responses, such as avoidance and alarm, that are likely to have provided early …