Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of
which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Premature termination codons (PTCs) cause a large proportion of inherited human genetic
diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway …

Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression.
Although lincRNAs are expressed in immune cells, their functions in immunity are largely …

Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in
mammals and is controlled by specialized RNA-binding proteins. The misregulation of …

Alternative splicing is regulated by multiple RNA-binding proteins and influences the
expression of most eukaryotic genes. However, the role of this process in human disease …

RNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA
transport, splicing, polyadenylation and stability. Understanding the interaction between …

Recently, pancreatic ductal adenocarcinoma (PDAC) has emerged as one of the most
aggressive malignant tumors with the worst prognosis. Previous studies have demonstrated …

Background Recent evidence suggests that RNA interaction can regulate the activity and
localization of chromatin-associated proteins. However, it is unknown if these observations …

Human genetic studies have identified the neuronal RNA binding protein, Rbfox1, as a
candidate gene for autism spectrum disorders. While Rbfox1 functions as a splicing …