Retinal ganglion cell neuronal damage in diabetes and diabetic retinopathy

DSK Ng, PPC Chiang, G Tan… - Clinical & …, 2016 - Wiley Online Library
Background To examine the association of diabetes and diabetic retinopathy (DR) with
retinal ganglion cell (RGC) loss. Design Observational case–control study. Participants Type …

Plasma metabonomic profiling of diabetic retinopathy

L Chen, CY Cheng, H Choi, MK Ikram… - Diabetes, 2016 - Am Diabetes Assoc
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
the leading cause of visual impairment in working-age adults. Patients with diabetes often …

A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

L Huang, H Zhang, CY Cheng, F Wen, POS Tam… - Nature …, 2016 - nature.com
Polypoidal choroidal vasculopathy (PCV), a subtype of'wet'age-related macular
degeneration (AMD), constitutes up to 55% of cases of wet AMD in Asian patients. In …

Comparison of common retinal vessel caliber measurement software and a conversion algorithm

WF Yip, YC Tham, W Hsu, ML Lee… - … vision science & …, 2016 - tvst.arvojournals.org
Purpose: To compare three commonly used retinal vessel caliber measurement software
systems, and propose an algorithm for conversion between measurement systems …

Association of vision impairment and major eye diseases with mobility and independence in a Chinese population

EK Fenwick, PG Ong, REK Man, CY Cheng… - JAMA …, 2016 - jamanetwork.com
Importance Mobility limitations arising from vision impairment (VI) can result in loss of
independence and reduced quality of life. However, few data are available on the …

Joint effects of intraocular pressure and myopia on risk of primary open-angle glaucoma: the Singapore epidemiology of eye diseases study

YC Tham, T Aung, Q Fan, SM Saw, RG Siantar… - Scientific reports, 2016 - nature.com
We examined the joint effects of intraocular pressure (IOP) and myopia on the risk of primary
open angle glaucoma (POAG) in a multi-ethnic Asian population. A total of 9,422 …

Vitamin D insufficiency and cognitive impairment in Asians: a multi‐ethnic population‐based study and meta‐analysis

C Annweiler, D Milea, HE Whitson… - Journal of internal …, 2016 - Wiley Online Library
Background The relationship between vitamin D insufficiency and cognitive impairment
remains equivocal in Asians. We examined the association between circulating 25 …

Retinal vein occlusion in a multi-ethnic asian population: the Singapore epidemiology of eye disease study

V Koh, CY Cheung, X Li, D Tian, JJ Wang… - Ophthalmic …, 2016 - Taylor & Francis
Purpose: To describe the prevalence of retinal vein occlusion (RVO) and its risk factors in a
multi-ethnic Asian population. Methods: This population-based study of 10,033 participants …

Polyphenol-enriched Vaccinium uliginosum L. fractions reduce retinal damage induced by blue light in A2E-laden ARPE19 cell cultures and mice

BL Lee, JH Kang, HM Kim, SH Jeong, DS Jang… - Nutrition research, 2016 - Elsevier
Polyphenols exert beneficial effects on vision. We hypothesized that polyphenol
components of Vaccinium uliginosum L.(VU) extract protect retinal pigment epithelial (RPE) …

Novel genetic loci associated with retinal microvascular diameter

RA Jensen, X Sim, AV Smith, X Li… - Circulation …, 2016 - Am Heart Assoc
Background—There is increasing evidence that retinal microvascular diameters are
associated with cardiovascular and cerebrovascular conditions. The shared genetic effects …