OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …

Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based
on analytical chemistry principles and technological tools, particularly mass spectrometry …

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

Background Higher circulating levels of the branched-chain amino acids (BCAAs; ie,
isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but …

Results: In plasma, concentrations of 6 out of 21 amino acids varied significantly by diet
group, with differences of− 13% to+ 16% between meat-eaters and vegans. Concentrations …

Dietary proteins are important modulators of glucose metabolism. However, few longitudinal
studies have evaluated the associations between intake of protein and protein type and risk …

Background Although obesity and cardiometabolic traits commonly overlap, underlying
pathways remain incompletely defined. The association of metabolite profiles across …

Recent studies have shown the positive association between increased circulating BCAAs
(valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients …

Background: Diet plays an important role in chronic disease etiology, but some diet-disease
associations remain inconclusive because of methodologic limitations in dietary …

OBJECTIVE Acylcarnitines were suggested as early biomarkers even prior to insulin
resistance in animal studies, but their roles in predicting type 2 diabetes were unknown …