Role of extracellular cysteine residues in the adenosine A2A receptor
E De Filippo, V Namasivayam, L Zappe, A El-Tayeb… - Purinergic …, 2016 - Springer
The G protein-coupled A 2A adenosine receptor represents an important drug target. Crystal
structures and modeling studies indicated that three disulfide bonds are formed between …
structures and modeling studies indicated that three disulfide bonds are formed between …
Conformational and thermodynamic landscape of GPCR activation from theory and computation
We present a hybrid computational methodology to predict multiple energetically accessible
conformations for G protein-coupled receptors (GPCRs) that might play a role in binding to …
conformations for G protein-coupled receptors (GPCRs) that might play a role in binding to …
Homology modeling and molecular docking studies of Drosophila and Aedes sex peptide receptors
J Kim, SK Kim, JH Lee, YJ Kim, WA Goddard III… - Journal of Molecular …, 2016 - Elsevier
The Drosophila melanogaster sex peptide receptor (DrmSPR), which is a G protein-coupled
receptor (GPCR), is known as the specific receptor for sex peptide (SP). It is responsible for …
receptor (GPCR), is known as the specific receptor for sex peptide (SP). It is responsible for …
Computational prediction and biochemical analyses of new inverse agonists for the CB1 receptor
CE Scott, KH Ahn, ST Graf, WA Goddard III… - Journal of chemical …, 2016 - ACS Publications
Human cannabinoid type 1 (CB1) G-protein coupled receptor is a potential therapeutic
target for obesity. The previously predicted and experimentally validated ensemble of ligand …
target for obesity. The previously predicted and experimentally validated ensemble of ligand …
Methods and systems for modulating hormones and related methods, agents and compositions
WA Goddard III, M Menna, S Pandol, R Abrol - US Patent 9,272,051, 2016 - Google Patents
US9272051B2 - Methods and systems for modulating hormones and related methods, agents
and compositions - Google Patents US9272051B2 - Methods and systems for modulating …
and compositions - Google Patents US9272051B2 - Methods and systems for modulating …
Classical Force Field Simulations of Biological Processes and Quantum Chemical Computations of Homogeneous Catalysts
F Liu - 2016 - thesis.library.caltech.edu
Computational chemistry methods and tools have enabled studies of biological processes
and chemical reactions to get insights from detailed atomic structures and reaction …
and chemical reactions to get insights from detailed atomic structures and reaction …
[PDF][PDF] Structural and functional characterization of G protein-coupled adenosine receptors and the orphan receptor GPR143
E De Filippo - 2016 - core.ac.uk
The G protein coupled-receptors (GPCRs) form one of the largest superfamily of proteins in
the mammalian genome, including more than 800 human genes [1]. Two main features …
the mammalian genome, including more than 800 human genes [1]. Two main features …