A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and
functions that are distinct from those of conventional B cells exist in mice. It contributes the …

The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly
in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 …

Fat-associated lymphoid clusters (FALC) are inducible structures that support rapid innate-
like B-cell immune responses in the serous cavities. Little is known about the physiological …

Post-traumatic stress disorder patients experience chronic systemic inflammation. However,
the molecular pathways involved and mechanisms regulating the expression of genes …

Chronic pulmonary infection with Pseudomonas aeruginosa is a feature of cystic fibrosis
(CF) and other chronic lung diseases. Cytokines of the interleukin-17 (IL-17) family have …

The skin is an important barrier organ and frequent target of autoimmunity and allergy. In this
study, we found innate-like B cells that expressed the anti-inflammatory cytokine IL-10 in the …

Acute peritonitis is a frequent medical condition that can trigger severe sepsis as a life-
threatening complication. Neutrophils are first-responders in infection but recruitment …

Oral symptoms are among the most distressing manifestations for patients with Sjögren's
syndrome (SS). The feeling of dry mouth is unpleasant, and hyposalivation may contribute to …

In mice, generation of autoreactive CD5+ B cells occurs as a consequence of BCR signaling
induced by (self)-ligand exposure from fetal/neonatal B-1 B cell development. A fraction of …

The majority of patients with epithelial ovarian cancer are diagnosed with advanced
disease. While many of these patients will respond initially to chemotherapy, the majority will …