Mitochondrial control of cell bioenergetics in Parkinson's disease

R Requejo-Aguilar, JP Bolaños - Free Radical Biology and Medicine, 2016 - Elsevier
Parkinson disease (PD) is a neurodegenerative disorder characterized by a selective loss of
dopaminergic neurons in the substantia nigra. The earliest biochemical signs of the disease …

Alzheimer's disease: from mitochondrial perturbations to mitochondrial medicine

S Cardoso, C Carvalho, SC Correia, RM Seiça… - Brain …, 2016 - Wiley Online Library
Age‐related neurodegenerative diseases such as Alzheimer's disease (AD) are distressing
conditions causing countless levels of suffering for which treatment is often insufficient or …

Muscle immobilization activates mitophagy and disrupts mitochondrial dynamics in mice

C Kang, D Yeo, LL Ji - Acta physiologica, 2016 - Wiley Online Library
Aim Skeletal muscle atrophy following prolonged immobilization (IM) is a catabolic state
characterized by increased proteolysis and functional deterioration. Previous research …

Menadione-induced DNA damage leads to mitochondrial dysfunction and fragmentation during rosette formation in Fuchs endothelial corneal dystrophy

A Halilovic, T Schmedt, AS Benischke… - Antioxidants & redox …, 2016 - liebertpub.com
Aims: Fuchs endothelial corneal dystrophy (FECD), a leading cause of age-related corneal
edema requiring transplantation, is characterized by rosette formation of corneal …

Polyphosphate as a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications

X Wang, HC Schröder, WEG Müller - Biotechnology Journal, 2016 - Wiley Online Library
In animals, energy‐rich molecules like ATP are generated in the intracellular compartment
from metabolites, eg glucose, taken up by the cells. Recent results revealed that inorganic …

Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA

A Malena, B Pantic, D Borgia, G Sgarbi, G Solaini… - Autophagy, 2016 - Taylor & Francis
Pathological mutations in the mitochondrial DNA (mtDNA) produce a diverse range of tissue-
specific diseases and the proportion of mutant mitochondrial DNA can increase or decrease …

Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup

HM Kuo, SW Weng, AYW Chang, HT Huang… - Free Radical Biology …, 2016 - Elsevier
The advantage of using a cytoplasmic hybrid (cybrid) model to study the genetic effects of
mitochondria is that the cells have the same nuclear genomic background. We previously …

[PDF][PDF] Adrenergic control of pinealocyte chondriome-an in vitro study

B Przybylska-Gomowicz, B Lewczuk… - Polish Journal of …, 2016 - bibliotekanauki.pl
Norepinephrine released from sympathetic innervation plays the main role in the regulation
of melatonin secretion in mammalian pinealocytes. The present study was conducted for the …

Association analysis between genes' variants for regulating mitochondrial dynamics and fasting blood glucose level

D Jung, HS Jin - Biomedical Science Letters, 2016 - koreascience.kr
Maintenance of fasting blood glucose levels is important for glucose homeostasis.
Disruption of feedback mechanisms are a major reason for elevations of glucose level in …

Utilising autophagy modulation to combat cell death resistance in Glioblastoma Multiforme

JA Kriel - 2016 - scholar.sun.ac.za
Abstract ENGLISH SUMMARY: Introduction: Globally, Glioblastoma Multiforme (GBM)
presents as both the most prevalent and invasive form of Central Nervous System (CNS) …