Metastasis is the main cause of death in people with cancer. To colonize distant organs,
circulating tumour cells must overcome many obstacles through mechanisms that we are …

The local extension of cancer cells along nerves is a frequent clinical finding for various
tumours. Traditionally, nerve invasion was assumed to occur via the path of least resistance; …

Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice
following a mechanism very similar to that observed in obese humans. The process initiates …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an exuberant inflammatory
desmoplastic response. The PDAC microenvironment is complex, containing both pro-and …

Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives
cancer progression, although the pathways of tumour cell dissemination are unclear. Here …

Nerves enable cancer progression, as cancers have been shown to extend along nerves
through the process of perineural invasion, which carries a poor prognosis. Furthermore, the …

The prostate gland mainly contains basal and luminal cells constructed as a pseudostratified
epithelium. Annotation of prostate epithelial transcriptomes provides a foundation for …

Cellular transformation and cancer progression is accompanied by changes in the metabolic
landscape. Master co-regulators of metabolism orchestrate the modulation of multiple …

Background & Aims Considerable evidence suggests that adrenergic signaling played an
essential role in tumor progression. However, its role in hepatocellular carcinoma (HCC) …

Optogenetic methodology enables direct targeting of specific neural circuit elements for
inhibition or excitation while spanning timescales from the acute (milliseconds) to the …