The nervous system and cardiovascular system develop in concert and are functionally
interconnected in both health and disease. This white paper focuses on the cellular and …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited cardiac
arrhythmia disorder that is characterized by emotion-and exercise-induced polymorphic …

CaMKII is a serine–threonine protein kinase that is abundant in myocardium. Emergent
evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) …

Increased sodium influx via incomplete inactivation of the major cardiac sodium channel
NaV1. 5 is correlated with an increased incidence of atrial fibrillation (AF) in humans. Here …

The specific effect of oxygen and reactive oxygen species (ROS) in mediating post-
translational modification of protein targets has emerged as a key mechanism regulating …

Although the initiation, development, and maintenance of atrial fibrillation (AF) have been
linked to alterations in myocyte redox state, the field lacks a complete understanding of the …

Atrial fibrillation (AF) is the most common sustained arrhythmia. AF is a complex disease that
results from genetic and environmental factors and their interactions. In recent years …

Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with increased risk
of cerebrovascular stroke, and with several other pathologies, including heart failure …

Reperfusion injury can exacerbate tissue damage in ischemic stroke, but little is known
about the mechanisms linking ROS to stroke severity. Here, we tested the hypothesis that …

Previous results from our laboratory showed that phosphorylation of ryanodine receptor 2
(RyR2) by Ca2+ calmodulin-dependent kinase II (CaMKII) was a critical but not the unique …