Communication among cells via direct cell-cell contact by connexin gap junctions, or
between cell and extracellular environment via pannexin channels or connexin …

Electron micrographs revealed the presence of gap junctions in osteoblastic cells over 40
years ago. These intercellular channels formed from connexins are present in bone forming …

Objectives Insulin-like growth factor 1 (IGF-1) is a broad-spectrum growth-promoting factor
that plays a key role in natural tooth development. Human dental pulp stem cells (hDPSCs) …

ABSTRACT Pannexin 3 (Panx3) and connexin 43 (Cx43; also known as GJA1) are two
major gap junction proteins expressed in osteoblasts. Here, we studied their functional …

The majority of the skeleton arises by endochondral ossification, whereby cartilaginous
templates expand and are resorbed by osteoclasts then replaced by osteoblastic bone …

Hearing loss, including noise-induced hearing loss, is highly prevalent and severely hinders
an individual's quality of life, yet many of the mechanisms that cause hearing loss are …

Pannexins form single‐membrane channels that allow passage of small molecules between
the intracellular and extracellular compartments. Of the three pannexin family members …

Chondrocytes in cartilage and bone cells population express connexin43 (Cx43) and gap
junction intercellular communication (GJIC) is essential to synchronize cells for coordinated …

Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their
function is the ability to respond to mechanical loads with changes of metabolic activity. This …

Background Body mass index (BMI) has been implicated as a primary factor influencing
cancer development. However, understanding the relationship between these two complex …