NK cell and CD4+ FoxP3+ regulatory T cell based therapies for hematopoietic stem cell engraftment

A Pierini, M Alvarez, RS Negrin - Stem cells international, 2016 - Wiley Online Library
Allogeneic hematopoietic cell transplantation (HCT) is a powerful therapy to treat multiple
hematological diseases. The intensive conditioning regimens used to allow for donor …

Activating receptors for self-MHC class I enhance effector functions and memory differentiation of NK cells during mouse cytomegalovirus infection

T Nabekura, LL Lanier - Immunity, 2016 - cell.com
Natural killer (NK) cells are important in host defense against pathogens, and they can
subsequently differentiate into memory NK cells. The Ly49 and KIR gene families in rodents …

Recognition of the major histocompatibility complex (MHC) class Ib molecule H2-Q10 by the natural killer cell receptor Ly49C

LC Sullivan, R Berry, N Sosnin, JML Widjaja… - Journal of Biological …, 2016 - ASBMB
Murine natural killer (NK) cells are regulated by the interaction of Ly49 receptors with major
histocompatibility complex class I molecules (MHC-I). Although the ligands for inhibitory …

Analysis of Ly49 gene transcripts in mature NK cells supports a role for the Pro1 element in gene activation, not gene expression

MV McCullen, H Li, M Cam, SK Sen, DW McVicar… - Genes & …, 2016 - nature.com
The variegated expression of murine Ly49 loci has been associated with the probabilistic
behavior of an upstream promoter active in immature cells, the Pro1 element. However …

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours

J Filtjens, J Keirsse, E Van Ammel, S Taveirne… - Scientific Reports, 2016 - nature.com
Natural killer (NK) lymphocytes are part of the innate immune system and are important in
immune protection against tumourigenesis. NK cells display a broad repertoire of activating …

树突状表皮T 淋巴细胞生物学特征及病理生理效应研究进展

李雅舒, 贺伟峰, 吴军 - 中华烧伤与创面修复杂志, 2016 - zhsszz.xml-journal.net
The maturation of dendritic epidermal T lymphocytes (DETCs) in thymus needs ligand-
mediated positive selection, and positive selection together with V3γ+ γδT lymphocytes …

The Ly49E Receptor Inhibits the Immune Control of Acute Trypanosoma cruzi Infection

J Filtjens, N Coltel, S Cencig, S Taveirne… - Frontiers in …, 2016 - frontiersin.org
The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and
invades various cells. Parasites intensively multiply during the acute phase of infection and …

Nucleosome presence at AML-1 binding sites inversely correlates with Ly49 expression: revelations from an informatics analysis of nucleosomes and immune cell …

A Wight, D Yang, I Ioshikhes… - PLoS Computational …, 2016 - journals.plos.org
Beyond its role in genomic organization and compaction, the nucleosome is believed to
participate in the regulation of gene transcription. Here, we report a computational method to …

Extrinsic allospecific signals of hematopoietic origin dictate iNKT cell lineage-fate decisions during development

BSI Strong, TJ Newkold, AE Lee, LE Turner… - Scientific reports, 2016 - nature.com
Invariant NKT (iNKT) cells are critical to the maintenance of tolerance toward alloantigens
encountered during postnatal life pointing to the existence of a process for self-education …

[图书][B] Bypassing NK cell tuning by targeting diacylglycerol kinase zeta, a distal regulator of signaling

EJ Yang - 2016 - search.proquest.com
NK cells are part of the innate immune system, and play an important role in viral and tumor
defense. Improving natural killer (NK) cell function could be beneficial for enhancing anti …