Chemokines and chemokine receptors are involved in leukocyte recruitment and
angiogenesis underlying the pathogenesis of rheumatoid arthritis (RA) and other …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is
characterized by synovial hyperplasia and progressive joint destruction. The activation of RA …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily
affects the joints. Self-reactive B and T lymphocytes cooperate to promote antibody …

At least 30% of patients with rheumatoid arthritis (RA) do not respond to biologic agents,
which emphasizes the need of predictive biomarkers. We aimed to identify microRNAs …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to
destructive arthritis. Although the HLA class II locus is the strongest genetic risk factor for …

The chemokine receptor CXCR4 is an important G protein-coupled receptor. Signaling via
CXCL12 regulates a number of important biologic processes, including immune responses …

Background Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease
among children, the etiology of which involves a strong genetic component, but much of the …

Antagonistic antibodies targeting the G-protein CXC chemokine receptor 4 (CXCR4) hold
promising therapeutic potential in various diseases. We report for the first time the detailed …

To date, several anti-human immunodeficiency virus (HIV) drugs such as reverse
transcriptase inhibitors, protease inhibitors and integrase inhibitors have been developed …

Notch signaling has recently emerged as an important regulator of immune responses in
autoimmune diseases. The recombination signal-binding protein for immunoglobulin kappa …