Chemical space of DNA-encoded libraries: Miniperspective
RM Franzini, C Randolph - Journal of medicinal chemistry, 2016 - ACS Publications
In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable
attention as a potential discovery tool in drug development. Screening encoded libraries …
attention as a potential discovery tool in drug development. Screening encoded libraries …
DNA-encoded chemical libraries: foundations and applications in lead discovery
G Zimmermann, D Neri - Drug Discovery Today, 2016 - Elsevier
Highlights•DNA-encoded chemical libraries: powerful means for hit identification in
pharma.•Link between the chemical building block and an amplifiable genetic …
pharma.•Link between the chemical building block and an amplifiable genetic …
Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties
DNA-encoded chemical libraries are increasingly used to identify leads for drug discovery or
chemical biology. Despite the resurging interest in covalent inhibitors, libraries are typically …
chemical biology. Despite the resurging interest in covalent inhibitors, libraries are typically …
Targeting allosteric control mechanisms in heat shock protein 70 (Hsp70)
Heat shock protein 70 (Hsp70) is a molecular chaperone that plays critical roles in protein
homeostasis. Hsp70's chaperone activity is coordinated by intra-molecular interactions …
homeostasis. Hsp70's chaperone activity is coordinated by intra-molecular interactions …
Novel PTP1B inhibitors identified by DNA display of fragment pairs
S Barluenga, C Zambaldo, HA Ioannidou… - Bioorganic & medicinal …, 2016 - Elsevier
DNA display of PNA-encoded libraries was used to pair fragments containing different
phosphotyrosine surrogates with diverse triazoles. Microarray-based screening of the …
phosphotyrosine surrogates with diverse triazoles. Microarray-based screening of the …
Seven-membered rings
This chapter aims to provide an overview of the key synthetic methods, reactions, and
applications reported in 2015 in the area of seven-membered heterocyclic compounds. Most …
applications reported in 2015 in the area of seven-membered heterocyclic compounds. Most …