Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …

The endothelial barrier maintains vascular and tissue homeostasis and modulates many
physiological processes, such as angiogenesis. Vascular barrier integrity can be disrupted …

Vascularization of bone defects is considered a crucial component to the successful
regeneration of large bone defects. Although vascular endothelial growth factor (VEGF) has …

Nerve injury is a serious complication associated with dental implant surgery. Following
nerve injury, the migration of Schwann cells (SCs) supports nerve regeneration …

Functional cross-talk between Tie2 and Integrin signaling pathways is essential to
coordinate endothelial cell adhesion and migration in response to the extracellular matrix …

Melanoma is notorious for its high tendency to metastasize and its refractoriness to
conventional treatments after metastasis, and the responses to most targeted therapies are …

The unique composition of tumor‐produced extracellular matrix (ECM) can be a determining
factor in changing the profile of endothelial cells in the tumor microenvironment. As the main …

The spatial organization of vascular endothelial growth factor (VEGF) signaling is a key
determinant of vascular patterning during development and tissue repair. How VEGF …

Vascular endothelial growth factor A (VEGF-A) is a key molecule in angiogenesis acting
through VEGF receptors (VEGFRs), α ν β 3 integrin, receptor protein tyrosine phosphatase …

As the populations of the Western world become older, they will suffer more and more from
bone defects related to osteoporosis (non-union fractures, vertebral damages), cancers …