Advancing the understanding of autism disease mechanisms through genetics
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …
fueled remarkable advances in our understanding of its potential neurobiological …
Developing and evaluating polygenic risk prediction models for stratified disease prevention
Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …
accordance with recent events, such as discoveries of large numbers of disease …
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …
previous genome-wide studies were unable to identify risk loci among individuals of …
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However …
variable. Previous studies have suggested that lithium response is a heritable trait. However …
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci
Meta-analyses of association results for blood pressure using exome-centric single-variant
and gene-based tests identified 31 new loci in a discovery stage among 146,562 …
and gene-based tests identified 31 new loci in a discovery stage among 146,562 …
[HTML][HTML] Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Neuroticism is a personality trait of fundamental importance for psychological well-being and
public health. It is strongly associated with major depressive disorder (MDD) and several …
public health. It is strongly associated with major depressive disorder (MDD) and several …
The road to precision psychiatry: translating genetics into disease mechanisms
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …
Fetal programming of neuropsychiatric disorders
G Faa, M Manchia, R Pintus, C Gerosa… - … Research Part C …, 2016 - Wiley Online Library
Starting from the Developmental Origins of Health and Disease (DOHaD) hypotheses
proposed by David Barker, namely fetal programming, in the past years, there is a growing …
proposed by David Barker, namely fetal programming, in the past years, there is a growing …
Polygenic dissection of major depression clinical heterogeneity
Y Milaneschi, F Lamers, WJ Peyrot, A Abdellaoui… - Molecular …, 2016 - nature.com
The molecular mechanisms underlying major depressive disorder (MDD) are largely
unknown. Limited success of previous genetics studies may be attributable to heterogeneity …
unknown. Limited success of previous genetics studies may be attributable to heterogeneity …