Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …

Despite marked improvements in the survival of patients with severe lupus nephritis over the
past 50 years, the rate of complete clinical remission after immune suppression therapy is< …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are the key
histological findings in patients with idiopathic nephrotic syndrome (INS). Although MCD and …

Glomerular diseases are common and important. They can arise from systemic inflammatory
or metabolic diseases that affect the kidney. Alternately, they are caused primarily by local …

It is currently postulated that steroid-sensitive idiopathic nephrotic syndrome (SSNS) and
steroid-resistant idiopathic nephrotic syndrome (SRNS), which are not related to the …

The Centers for Disease Control and Prevention estimates more than 10% of adults in the
United States, over 20 million Americans, have chronic kidney disease (CKD). A failure to …

FSGS is a common glomerular disorder that has a high propensity for recurrence after
kidney transplant. The pathophysiology of FSGS is unknown, but podocytes seem to be the …

Glomerular injury often incites a progression to chronic kidney disease, which affects
millions of patients worldwide. Despite our current understanding of this disease's …

Minimal change nephrosis (MCN) is an important cause of morbidity in children. In spite of
successful therapies having been developed in the last three decades, most aspects related …