The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …

Vascular remodelling is a multifactorial process that involves both adaptive and maladaptive
changes of the vessel wall through, among others, cell proliferation and migration, but also …

Background: GTP cyclohydrolase 1 (GCH1) deficiency is critical for endothelial nitric oxide
synthase uncoupling in endothelial dysfunction. MicroRNAs (miRs) are a class of regulatory …

Cardiac fibrosis as a result of excessive extracellular matrix deposition leads to stiffening of
the heart, which can eventually lead to heart failure. An important event in cardiac fibrosis is …

Purpose Abdominal aortic aneurysm is a common degenerative vascular disorder
associated with sudden death due to aortic rupture. This review describes epidemiology …

The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its
homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth …

Abstract Aims Circulating microRNAs (miRs) may reflect pathophysiologically relevant
processes in the atherosclerotically diseased coronary arterial wall. Given the unmet …

Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial
infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve …

Background: Patients with a bicuspid aortic valve (BAV) are at increased risk for progressive
aortic dilation associated with extracellular matrix (ECM) degradation by matrix …