Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

Recognition of DNA by the cell is an important immunological signature that marks the
initiation of an innate immune response. AIM2 is a cytoplasmic sensor that recognizes …

Environmental exposures and the development of systemic lupu... : Current Opinion in
Rheumatology Environmental exposures and the development of systemic lupus erythematosus …

Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …

The genome-wide association study is a free-hypothesis approach based on screening of
thousands or even millions of genetic variants distributed throughout the whole human …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Objective Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease with
limited reliable diagnostic biomarkers. We investigated whether gene methylation could …

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation …

Biobanking is a widespread practice for storing biological samples for future studies ranging
from genotyping to RNA analysis. However, methods that probe the status of the epigenome …

Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that
maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA …