Protein misfolding and aggregation are a hallmark of several neurodegenerative diseases
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …

In healthy cell, inappropriate accumulation of poor or damaged proteins is prevented by
cellular quality control system. Autophagy and ubiquitin proteasome system (UPS) provides …

Aβ 43, a product of the proteolysis of the amyloid precursor protein APP, is related to Aβ 42
by an additional Thr residue at the C-terminus. Aβ 43 is typically generated at low levels …

Toxic human amylin (hA) oligomers and aggregates are implicated in the pathogenesis of
type 2 diabetes mellitus (T2DM). Although recent studies demonstrated a causal connection …

Proteins with expanded polyglutamine (polyQ) regions are prone to form amyloids, which
can cause diseases in humans and toxicity in yeast. Recently, we showed that in yeast non …

The transcription factor Suppressor of Hairless and its coactivator, the Notch intracellular
domain, are polyglutamine (pQ)-rich factors that target enhancer elements and interact with …

RUB-Repository - Conformational dynamics and aggregation of Huntingtin Exon 1 in living
cells Deutsch OPUS UB Bochum RUB » Bibliotheksportal Home Search Browse Publish …

Cell signaling pathways are frequently used in multiple tissue and stage-specific contexts
during multicellular development. The integration of these signaling pathways by …

Abstract Spinocerebellar ataxia type-3 (SCA3), also known as Machado-Joseph disease, is
proposed to be the most common dominant autosomal ataxia. It is a progressive, fatal …

The transcription factor Suppressor of Hairless and its co-activator, the Notch intracellular
domain, are polyglutamine (pQ)-rich factors that target enhancer elements and interact with …