Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Vertebrate life critically depends on renal filtration and excretion of low molecular weight
waste products. This process is controlled by a specialized cell-cell contact between …

Ultimately, the common final pathway of any glomerular disease is podocyte effacement,
podocyte loss, and, eventually, glomerular scarring. There has been a long-standing debate …

Glomerular permeability and subsequent albuminuria are early clinical markers for
glomerular injury in hypertensive nephropathy. Albuminuria predicts mortality and …

CD2-associated protein is one of the most important slit diaphragm proteins in maintaining
podocyte integrity and reducing proteinuria. In the last 15 years, progressive researches …

Nephrin belongs to a family of highly conserved proteins with a well characterized function
as modulators of cell adhesion and guidance, and nephrin may have a role in metabolic …

Kidneys serve as an important metabolic organ that eliminates nitrogenous waste products,
maintains uid and electrolyte balance, and performs important hormonal functions, such as …

The nephrotic syndrome (NS) is characterized by massive proteinuria, edema and
hypertriglyceridemia. It can appear as a primary or a secondary disease, idiopathic or …