To serve vision, vertebrate rod and cone photoreceptors must detect photons, convert the
light stimuli into cellular signals, and then convey the encoded information to downstream …

Pancreatic cancer (PaCa) has the highest death rate and incidence is increasing. Poor
prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor …

Blood vessels are part of the stem cell niche in the developing cerebral cortex, but their in
vivo role in controlling the expansion and differentiation of neural stem cells (NSC s) in …

We report that the protein kinase Cι (PKCι) oncogene controls expression of NOTCH3, a key
driver of stemness, in KRAS-mediated lung adenocarcinoma (LADC). PKCι activates …

Microglia begin colonizing the developing brain as early as embryonic day 9, prior to the
emergence of neurons and other glia. Their ontogeny is also distinct from other central …

Background The microvillus is a versatile organelle that serves important functions in
disparate animal cell types. However, from a molecular perspective, the microvillus has …

Cancer stem cells (CSCs) are a small subpopulation of tumor cells with capabilities of self-
renewal, dedifferentiation, tumorigenicity, and inherent chemo-and-radio therapy resistance …

The process of myeloid cell development (myelopoiesis) in fish has mainly been studied in
three cyprinid species: zebrafish (Danio rerio), ginbuna carp (Carassius auratus langsdorfii) …

BACKGROUND: Nestin, CD133 and ABCG2 are recently discussed as putative markers, co-
expression of which might determine a cancer stem cell (CSC) phenotype in sarcomas …

Compared to normal kidney, renal clear cell carcinomas (ccRCC) contain increased
numbers of interstitial, non-hematopoietic CD133+ cells that express stem cell markers and …