The polymyxin antibiotics [colistin and polymyxin B (PMB)] are increasingly used as a last-
line option for the treatment of infections caused by extensively drug-resistant Gram …

The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections due to …

Gram-negative bacteria cause infections that are difficult to treat due to the emergence of
multidrug resistance. This review summarizes the current status of the studies investigating …

Administering polymyxin antibiotics in a traditional fashion may be ineffective against Gram-
negative ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …

Nosocomial and community-acquired infections caused by multidrug resistant bacteria
represent a major human health problem. Thus, there is an urgent need for the development …

Objectives Polymyxin B is being increasingly utilized as a last resort against resistant Gram-
negative bacteria. We examined the pharmacodynamics of novel dosing strategies for …

Polymyxin B is increasingly used as a treatment of last resort for multidrug-resistant Gram-
negative infections. Despite being available as a mixture of several structurally related …

Development of spontaneous mutations in Pseudomonas aeruginosa has been associated
with antibiotic failure, leading to high rates of morbidity and mortality. Our objective was to …

Against extensively drug-resistant (XDR) Enterobacter cloacae, combination antibiotic
therapy may be the only option. We investigated the activity of various antibiotics in …

Background Direct hemoperfusion with a polymyxin B-immobilized column (PMX-DHP)
adsorbs endotoxin and has been used for the treatment of septic shock. Yet, the …