Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

The gastrointestinal tract presents a unique challenge to the mucosal immune system, which
has to constantly monitor the vast surface for the presence of pathogens, while at the same …

Inflammatory bowel disease (IBD) is associated with risk variants in the human genome and
dysbiosis of the gut microbiome, though unifying principles for these findings remain largely …

FOXP3+ regulatory T cells (Tregs) maintain tolerance against self-antigens and innocuous
environmental antigens. However, it is still unknown whether Treg-mediated tolerance is …

With extension of the average lifespan, aging has become a heavy burden in society.
Immune senescence is a key risk factor for many age-related diseases such as cancer and …

Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and
avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways …

Regulatory T cells (Tregs), lymphocytes that suppress immunological reactions, are of great
interest for our comprehension of basic immunology and as a therapeutic agent to treat …