Treatment for cystic fibrosis (CF) has conventionally targeted downstream consequences of
the defect such as mucus plugging and infection. More recently, significant advances have …

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Cystic fibrosis (CF) is an inherited disease associated with chronic severe lung
inflammation, leading to premature death. To develop innovative anti-inflammatory …

Background Chronic neutrophilic inflammation, in both the presence and absence of
infection, is a feature of bronchiectasis in adults and children. The anti‐inflammatory …

Endoplasmic reticulum (ER) stress has been recognized to play an important role in chronic
inflammatory diseases like cystic fibrosis (CF) and targeting ER stress may be useful for …

Introduction The approved analgesic and anti-inflammatory drugs ibuprofen and
indometacin block the small GTPase RhoA, a key enzyme that impedes axonal sprouting …

Background and Purpose Pulmonary disease is the main cause of morbidity and mortality in
cystic fibrosis (CF) patients due to exacerbated inflammation. To date, the only anti …

Health management of cystic fibrosis (CF) patients should be maximized during pregnancy
and breastfeeding because of its significant impact on the maternal and newborn outcomes …

I. Introduction Although cystic fibrosis (CF) impacts nearly every organ system, lung disease
accounts for most of the morbidity and mortality (1). Epithelial cells, particularly those of …

Background: Patients with cystic fibrosis have poor lung function and chronic infections
which impair the quality of life and are the leading cause of death. Hypogammaglobulinemia …