[HTML][HTML] Critical role of intracellular RyR1 calcium release channels in skeletal muscle function and disease

EO Hernández-Ochoa, SJP Pratt, RM Lovering… - Frontiers in …, 2016 - frontiersin.org
The skeletal muscle Ca2+ release channel, also known as ryanodine receptor type 1
(RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle …

The Role of Phospholamban and Sarcolipin in Skeletal Muscle Disease

VA Fajardo - 2016 - uwspace.uwaterloo.ca
Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that physically interact
with and inhibit the sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA) pump. Results …

Changes in cytosolic Ca2+ dynamics in the sarcoplasmic reticulum associated with the pathology of Duchenne muscular dystrophy

J Tanihata, S Takeda - The Journal of Physical Fitness and Sports …, 2016 - jstage.jst.go.jp
Duchenne muscular dystrophy (DMD) is a life-limiting X-linked genetic disorder caused by a
lack of the membrane-associated protein dystrophin. The absence of dystrophin increases …

Identification of Small Ankyrin 1 as a novel SERCA1 regulatory protein in Skeletal Muscle

PF Desmond - 2016 - search.proquest.com
Abstract Small Ankyrin 1 (sAnk1) is a∼ 20 kDa transmembrane (TM) protein that binds to the
cytoskeletal protein, obscurin, and stabilizes the network sarcoplasmic reticulum (nSR) in …

The role of intracellular calcium perturbations in muscle damage and dysfunction in mouse models of muscular dystrophy

DAG Mazala - 2016 - search.proquest.com
Duchenne muscular dystrophy (DMD) is a neuromuscular disease caused by mutations in
the dystrophin gene. DMD is clinically characterized by severe, progressive and irreversible …