When administering eye drops, even when completely correctly applied, several routes of
absorption are possible and excess amounts can sometimes cause an unwanted systemic …

Introduction: It is generally believed that topical administration of eye drops safeguards
against harmful systemic effects. However, about 80% of the drug in the ophthalmic products …

The accurate prediction of pharmacokinetics (PK) is fundamental to underwriting safety and
efficacy in pediatric clinical trials; age‐dependent PK may be observed with pediatrics …

Human growth and development consist of a continuum of biological events. The impact of
these developmental changes in drug disposition is largely related to changes in the body …

Membrane transporters play an essential role in the transport of endogenous and
exogenous compounds, and consequently they mediate the uptake, distribution, and …

The xenobiotic-sensing transcription factors (xeno-sensors) AhR, CAR, and PXR upregulate
the expression of many drug-processing genes (DPGs) in liver. Previous studies have …

Atomoxetine (ATX) is a second-line nonstimulant medication used to control symptoms of
attention deficit hyperactivity disorder (ADHD). Inconsistent therapeutic efficacy has been …

Background: This study determined whether the SLC22A1 [encoding the organic cation
transporter 1 (OCT1)] genotype could explain, in addition to the postmenstrual age (referring …

Pharmacogenomic (PGx) information is increasingly being incorporated into US Food and
Drug Administration‐approved drug labels. We reviewed the data source (adults vs …

Serotonin reuptake inhibitors (SRIs) are often prescribed during pregnancy. Previous
studies that found an increased risk of congenital anomalies, particularly congenital heart …