Several preclinical and some clinical studies have revealed that the mammalian target of
rapamycin (mTOR) signaling pathway is involved in both genetic and acquired epilepsy …

Despite the revolution in recent decades regarding monoamine involvement in the
management of major depressive disorder (MDD), the biological mechanisms underlying …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

A large body of evidence indicates alterations in brain regional cellular energy metabolism
and blood flow in schizophrenia. Among the different molecules regulating blood flow …

In order to investigate the effects of glucocorticoid excess in rodent models, reliable methods
of continuous glucocorticoid delivery are essential. The current study compares two methods …

The Akt signaling pathway involves various cellular processes and depends on extracellular
stimuli. Since Akt signaling participates in cytoprotection, synapse plasticity, axon extension …

Everolimus (EVR) is an orally-administered rapamycin analog that selectively inhibits the
mammalian target of rapamycin (mTOR) kinase (mainly mTORC1 and likely mTORC2) and …

Two binding requirements for in vitro studies on long‐term neuronal networks dynamics are
(i) finely controlled environmental conditions to keep neuronal cultures viable and provide …

Ortho-substituted polychlorinated biphenyls (PCBs) preferentially accumulate in the brain
and cerebrospinal fluid (CSF) compared with other PCBs. We previously demonstrated in …

Increased blood vessel density could increase the efficiency of the glymphatic system which
removes waste from the brain. This study tested the hypothesis that chronic sleep restriction …