Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

Cancer is an evolutionary disease, containing the hallmarks of an asexually reproducing
unicellular organism subject to evolutionary paradigms. Pancreatic ductal adenocarcinoma …

Myxococcus xanthus, like other myxobacteria, is a social bacterium that moves and feeds
cooperatively in predatory groups. On surfaces, rod-shaped vegetative cells move in search …

The transition to multicellularity has occurred numerous times in all domains of life, yet its
initial steps are poorly understood. The volvocine green algae are a tractable system for …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Background Drug-induced drug resistance in cancer has been attributed to diverse
biological mechanisms at the individual cell or cell population scale, relying on …

Background A thorough understanding of the ecological and evolutionary mechanisms that
drive the phenotypic evolution of neoplastic cells is a timely and key challenge for the cancer …

The collection of evolutionary transformations known as the 'major transitions' or 'transitions
in individuality'resulted in changes in the units of evolution and in the hierarchical structure …

To form and maintain organized tissues, multicellular organisms orient their mitotic spindles
relative to neighboring cells. A molecular complex scaffolded by the GK protein-interaction …

Microbes are generally thought of as unicellular organisms, but we know that many
microbes live as parts of biofilms—complex, surface-attached microbial communities …