Behçet's disease, also known as the Silk Road Disease, is a rare systemic vasculitis
disorder of unknown etiology. Recurrent attacks of acute inflammation characterize Behçet's …

Germinal centers (GC) are the main sites where antigen‐activated B‐cell clones expand and
undergo immunoglobulin gene hypermutation and selection. Iterations of this process will …

Germinal center (GC) B cells undergo affinity selection, which depends on interactions with
CD4+ follicular helper T cells (TFH cells). We found that TFH cells progressed through …

T-bet and CD11c expression in B cells is linked with IgG 2c isotype switching, virus-specific
immune responses, and humoral autoimmunity. However, the activation requisites and …

Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA)
genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly …

IL-21 is a type I cytokine produced by T cells and natural killer T cells that has pleiotropic
actions on a wide range of immune and non-immune cell types. Since its discovery in 2000 …

The follicular helper T (Tfh) cells help is critical for activation of B cells, antibody class
switching, and germinal center (GC) formation. The Tfh cells are characterized by the …

CD4+ T follicular helper (Tfh) cells are recognized as a distinct T-cell subset, which provides
help for germinal center (GC) formation, B-cell development and affinity maturation, and …

Follicular helper T cells (Tfh) are located within germinal centers of lymph nodes. Cognate
interaction between Tfh, B cells, and IL‐21 drives B cells to proliferate and differentiate into …

We previously reported that SM934, a water-soluble artemisinin derivative, was a viable
treatment in murine lupus models. In the current study, we further investigated the …