Dopamine selectively remediates 'model-based'reward learning: a computational approach
Patients with loss of dopamine due to Parkinson's disease are impaired at learning from
reward. However, it remains unknown precisely which aspect of learning is impaired. In …
reward. However, it remains unknown precisely which aspect of learning is impaired. In …
Atomoxetine restores the response inhibition network in Parkinson's disease
Parkinson's disease impairs the inhibition of responses, and whilst impulsivity is mild for
some patients, severe impulse control disorders affect∼ 10% of cases. Based on preclinical …
some patients, severe impulse control disorders affect∼ 10% of cases. Based on preclinical …
Different decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson's disease
Progressive supranuclear palsy and Parkinson's disease have distinct underlying
neuropathology, but both diseases affect cognitive function in addition to causing a …
neuropathology, but both diseases affect cognitive function in addition to causing a …
Predicting beneficial effects of atomoxetine and citalopram on response inhibition in P arkinson's disease with clinical and neuroimaging measures
Recent studies indicate that selective noradrenergic (atomoxetine) and serotonergic
(citalopram) reuptake inhibitors may improve response inhibition in selected patients with …
(citalopram) reuptake inhibitors may improve response inhibition in selected patients with …
Differential involvement of brainstem noradrenergic and midbrain dopaminergic nuclei in cognitive control
S Köhler, KJ Bär, G Wagner - Human brain mapping, 2016 - Wiley Online Library
Several lines of evidence suggest that the lateral prefrontal cortex (PFC), the dorsal anterior
cingulate cortex (dACC), the parietal cortex, and the thalamus are central cortical nodes in a …
cingulate cortex (dACC), the parietal cortex, and the thalamus are central cortical nodes in a …
[HTML][HTML] Trait impulsivity and anhedonia: two gateways for the development of impulse control disorders in Parkinson's disease?
Apathy and impulsivity are two major comorbid syndromes of Parkinson's disease (PD) that
may represent two extremes of a behavioral spectrum modulated by dopamine-dependent …
may represent two extremes of a behavioral spectrum modulated by dopamine-dependent …
Atomoxetine enhances connectivity of prefrontal networks in Parkinson's disease
Cognitive impairment is common in Parkinson's disease (PD), but often not improved by
dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits …
dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits …
A multidimensional approach to impulsivity in Parkinson's disease: measurement and structural invariance of the UPPS Impulsive Behaviour Scale
BackgroundPoor impulse control is a common feature in patients with Parkinson's disease
(PD). However, before testing whether patients with PD and controls differ in impulsivity, one …
(PD). However, before testing whether patients with PD and controls differ in impulsivity, one …
Time on timing: dissociating premature responding from interval sensitivity in Parkinson's disease
Background Parkinson's disease (PD) can cause impulsivity with premature responses, but
there are several potential mechanisms. We proposed a distinction between poor decision …
there are several potential mechanisms. We proposed a distinction between poor decision …
Trial-to-trial adaptation: parsing out the roles of cerebellum and BG in predictive motor timing
OV Lungu, M Bares, T Liu, CM Gomez… - Journal of cognitive …, 2016 - direct.mit.edu
We previously demonstrated that predictive motor timing (ie, timing requiring visuomotor
coordination in anticipation of a future event, such as catching or batting a ball) is impaired …
coordination in anticipation of a future event, such as catching or batting a ball) is impaired …