Neurobiology of 3, 4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinovalerophenone (α-PVP)

RA Glennon, R Young - Brain research bulletin, 2016 - Elsevier
Synthetic cathinones are analogs of cathinone or β-ketoamphetamine–the major
psychostimulant component of the shrub Catha edulis or khat. Cathinone analogs–though …

Synthetic cathinone pharmacokinetics, analytical methods, and toxicological findings from human performance and postmortem cases

KN Ellefsen, M Concheiro, MA Huestis - Drug metabolism reviews, 2016 - Taylor & Francis
Synthetic cathinones are commonly abused novel psychoactive substances (NPS). We
present a comprehensive systematic review addressing in vitro and in vivo synthetic …

The toxicology of new psychoactive substances: synthetic cathinones and phenylethylamines

E Tyrkkö, M Andersson… - Therapeutic drug …, 2016 - journals.lww.com
Background: New psychoactive substances (NPSs) are substitutes for classical drugs of
abuse and there are now compounds available from all groups of classical drugs of abuse …

New psychoactive substances as part of polydrug abuse within opioid maintenance treatment revealed by comprehensive high‐resolution mass spectrometric urine …

P Heikman, M Sundström, A Pelander… - Human …, 2016 - Wiley Online Library
Objective At present, polydrug abuse comprises, besides traditional illicit drugs, new
psychoactive substances (NPS) and non‐prescribed psychotropic medicines (N‐PPM) …

α-PVP (“flakka”): a new synthetic cathinone invades the drug arena

M Katselou, I Papoutsis, P Nikolaou, C Spiliopoulou… - Forensic …, 2016 - Springer
Abstract “Flakka” is the street name for the synthetic cathinone α-pyrrolidinopentiophenone
(α-PVP). Although it was developed by Boehringer Ingelheim as a central nervous system …

4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry

KN Ellefsen, A Wohlfarth, MJ Swortwood, X Diao… - Forensic toxicology, 2016 - Springer
Novel psychoactive substances are continuously developed to circumvent legislative and
regulatory efforts. A new synthetic cathinone, 4-methoxy-α-PVP, was identified for the first …

Blood concentrations of α-pyrrolidinovalerophenone (α-PVP) determined in 66 forensic samples

P Adamowicz, J Gieroń, D Gil, W Lechowicz… - Forensic …, 2016 - Springer
Abstract α-Pyrrolidinovalerophenone (α-PVP) is a synthetic derivative of the cathinone,
which is one of the most popular new psychoactive substances (NPSs) in Poland in recent …

New psychoactive substance α-PVP in a traffic accident case

S Rojek, K Kula, M Maciów-Głąb, M Kłys - Forensic toxicology, 2016 - Springer
The problems of new psychoactive substances (NPSs), especially related to drivers,
constitute an open research area. In this case report, we present a traffic accident case, in …

Identification and characterization of new designer drug 4-fluoro-PV9 and α-PHP in the seized materials

M Majchrzak, M Rojkiewicz, R Celiński, P Kuś… - Forensic toxicology, 2016 - Springer
In this study, we present identification and physicochemical characterization of new
cathinone derivatives, 4-fluoro-PV9 and already known α-PHP in seized materials. Although …

The dangerous new synthetic drug α-PVP as the hydrated chloride salt α-pyrrolidinopentiophenone hydrochloride 0.786-hydrate

MR Wood, I Bernal, RA Lalancette - Acta Crystallographica Section C …, 2016 - scripts.iucr.org
α-Pyrrolidinovalerophenone (α-PVP), a dangerous designer drug, is now being marketed
around the world as a harmlessbath salt', when in reality it is a powerful β-ketone …