Immunomodulatory effects of tick saliva on dermal cells exposed to Borrelia burgdorferi, the agent of Lyme disease

DC Scholl, ME Embers, JR Caskey, D Kaushal… - Parasites & vectors, 2016 - Springer
Background The prolonged feeding process of ixodid ticks, in combination with bacterial
transmission, should lead to a robust inflammatory response at the blood-feeding site. Yet …

Borrelia burgdorferi Induces TLR2-Mediated Migration of Activated Dendritic Cells in an Ex Vivo Human Skin Model

LMK Mason, A Wagemakers, C van 't Veer, A Oei… - PLoS …, 2016 - journals.plos.org
Borrelia burgdorferi is transmitted into the skin of the host where it encounters and interacts
with two dendritic cell (DC) subsets; Langerhans cells (LCs) and dermal DCs (DDCs). These …

Homogeneous Inflammatory Gene Profiles Induced in Human Dermal Fibroblasts in Response to the Three Main Species of Borrelia burgdorferi sensu lato

M Meddeb, W Carpentier, N Cagnard, S Nadaud… - PLoS …, 2016 - journals.plos.org
In Lyme borreliosis, the skin is the key site for bacterial inoculation by the infected tick and
for cutaneous manifestations. We previously showed that different strains of Borrelia …

Lyme borreliosis

HI Huppertz, HJ Girschick - Handbook of Systemic Autoimmune Diseases, 2016 - Elsevier
Borrelia burgdorferi is the causative agent of Lyme borreliosis (LB). Clinical manifestations
of LB include chronic inflammatory disorders of skin, central nervous system, and joints …

[PDF][PDF] LYME DISEASE: THE IMMUNOLOGICAL RESPONSE TO BORRELIA BURGDORFERI

AG HARRISON - 2016 - researchgate.net
Lyme disease or Lyme borreliosis, which is caused by the tick-borne spirochete Borrelia
burgdorferi, is the most prevalent vector-borne illness in the United States and Europe. The …