In recognition of the enormous potential of immunotherapies against cancer, research into
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …

Development of predictive multi-organ models before implementing costly clinical trials is
central for screening the toxicity, efficacy, and side effects of new therapeutic agents. Despite …

Aptamers have recently emerged as reliable and promising targeting agents in the field of
biology. However, their therapeutic potential has yet to be completely assessed due to their …

Highlights•Skin disease drug development requires immune-competent in vitro human
models.•Skin disease examples: fibrosis, autoimmune, psoriasis, cancer and contact …

The microvasculature is an extensive, heterogeneous, and complex system that plays a
critical role in human physiology and disease. It nourishes almost all living human cells and …

Cell migration through three-dimensional (3D) tissue spaces is integral to many biological
and pathological processes, including metastasis. Circulating tumor cells (CTCs) are …

Inflammation is an indispensable component of the immune response, and leukocytes
provide the first line of defense against infection. Although the major stereotypic leukocyte …

In this chapter, we describe culture methods to construct microvascular networks as well as
approaches to integrating capillary networks with 3D epithelial tissue-engineered constructs …

The microvasculature is an extensive, heterogeneous, and complex system that plays a
critical role in human physiology and disease. It nourishes almost all living human cells and …