Oligodendrocytes readily regenerate and replace myelin membranes around axons in the
adult mammalian central nervous system (CNS) following injury. The ability to regenerate …

Today, there is enormous progress in understanding the function of glial cells, including
astroglia, oligodendroglia, Schwann cells, and microglia. Around 150 years ago, glia were …

While it has recently been shown that sildenafil (Viagra®) has a protective effect on
myelination/remyelination, the mechanism of this protection is still unknown. In general …

Oligodendrocytes wrap neuronal axons to form myelin, an insulating sheath which is
essential for nervous impulse conduction along axons. Axonal myelination is highly …

Ellagic acid (EA) is a natural phenol antioxidant with various therapeutic activities. However,
the efficacy of EA has not been examined in neuro-inflammatory conditions. Microglia …

White matter disease afflicts both developing and mature central nervous systems. Both cell
intrinsic and extrinsic dysregulation result in profound changes in cell survival, axonal …

Abstract Human immunodeficiency virus-1 (HIV-1)-associated neurocognitive disorder
(HAND) is a subcortical disease involving neuronal loss and myelin damage. Myelin is …

Neurodegenerative changes occurring early from primary acute immune-mediated
inflammation support the hypothesis that multiple sclerosis (MS) is a complex disease …

ヒトの脳は, 神経細胞とほぼ同数のグリア細胞で構成されており, 中枢神経系のグリア細胞には,
アストロサイト, オリゴデンドロサイト及びミクログリアがある. グリア細胞の中で大部分を占める …