Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …

Modern strategies in drug development employ in silico techniques in the design of
compounds as well as estimations of pharmacokinetics, pharmacodynamics and toxicity …

Pseudomonas aeruginosa is a remarkably versatile environmental bacterium with an
extraordinary capacity to infect the cystic fibrosis (CF) lung. Infection with P. aeruginosa …

Abnormalities in mucus production and qualitative properties such as mucus hydration are
central to the pathophysiology of airway disease including cystic fibrosis, asthma, and …

Background Respiratory syncytial virus infection causes acute lung infection in infants and
young children worldwide, resulting in considerable morbidity and mortality. Children with …

Defective epithelial chloride secretion occurs in humans with cystic fibrosis (CF), a genetic
defect due to loss of function of CFTR, a cAMP-activated chloride channel. In the airways …

The current options for objective assessment of nasal breathing are limited. The maximum
they can determine is the total nasal resistance. Possibilities to analyze the endonasal …

Chronic obstructive pulmonary disease (COPD) the third leading cause of death, with an
estimated 65 million cases worldwide. Despite this, most research to date has focused on …

Airway diseases that are clinically characterized by mucous hypersecretion are associated
with dehydrated secretions and impaired mucociliary clearance. The failure to clear pro …

Human lungs maintain proper airway surface liquid homeostasis for mucociliary clearance,
hydration, and as the first line of defense against inhaled pathogens. In Cystic Fibrosis, the …