ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

Neuroblastoma is an embryonal malignancy that commonly affects young children and is
remarkably heterogenous in its malignant potential. Recently, the genetic basis of …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the
development of different tumor types. Despite the remarkable clinical activity of crizotinib …

Neuroblastomas harboring activating point mutations in anaplastic lymphoma kinase (ALK)
are differentially sensitive to the ALK inhibitor crizotinib, with certain mutations conferring …

Background Gene annotations, such as those in GENCODE, are derived primarily from
alignments of spliced cDNA sequences and protein sequences. The impact of RNA-seq data …

The crizotinib-resistant ALK F1174L mutation arises de novo in neuroblastoma (NB) and is
acquired in ALK translocation-driven cancers, lending impetus to the development of novel …

Purpose: The presence of an ALK aberration correlates with inferior survival for patients with
high-risk neuroblastoma. The emergence of ALK inhibitors such as crizotinib has provided …

Neuroblastoma (NB) is one of the most common and deadly childhood solid tumors. These
tumors are characterized by clinical heterogeneity, from spontaneous regression to …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

This report describes a novel, one-pot synthesis of hybrid nanoparticles formed by a
nanostructured inorganic silica core and an organic pH-responsive hydrogel shell. This easy …