Sex differences in lifespan
SN Austad, KE Fischer - Cell metabolism, 2016 - cell.com
Sex differences in longevity can provide insights into novel mechanisms of aging, yet they
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …
Insulin resistance and Parkinson's disease: a new target for disease modification?
D Athauda, T Foltynie - Progress in neurobiology, 2016 - Elsevier
There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …
developing Parkinson's disease and share similar dysregulated pathways suggesting …
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Cellular senescence, a stress-induced irreversible growth arrest often characterized by
expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a …
expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a …
Calorie restriction as an intervention in ageing
G López‐Lluch, P Navas - The Journal of physiology, 2016 - Wiley Online Library
Ageing causes loss of function in tissues and organs, is accompanied by a chronic
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …
'Adipaging': ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
LM Pérez, H Pareja‐Galeano… - The Journal of …, 2016 - Wiley Online Library
The increasing ageing of our societies is accompanied by a pandemic of obesity and related
cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is …
cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is …
Signaling networks determining life span
CE Riera, C Merkwirth… - Annual review of …, 2016 - annualreviews.org
The health of an organism is orchestrated by a multitude of molecular and biochemical
networks responsible for ensuring homeostasis within cells and tissues. However, upon …
networks responsible for ensuring homeostasis within cells and tissues. However, upon …
Dietary protein, metabolism, and aging
GA Soultoukis, L Partridge - Annual review of biochemistry, 2016 - annualreviews.org
Dietary restriction (DR), a moderate reduction in food intake, improves health during aging
and extends life span across multiple species. Specific nutrients, rather than overall calories …
and extends life span across multiple species. Specific nutrients, rather than overall calories …
[PDF][PDF] Neuroendocrine regulation of growth hormone secretion
This article reviews the main findings that emerged in the intervening years since the
previous volume on hormonal control of growth in the section on the endocrine system of the …
previous volume on hormonal control of growth in the section on the endocrine system of the …
Targeting glucose metabolism for healthy aging
RA Brewer, VK Gibbs… - Nutrition and healthy …, 2016 - content.iospress.com
Advancing age is the greatest single risk factor for numerous chronic diseases. Thus, the
ability to target the aging process can facilitate improved healthspan and potentially lifespan …
ability to target the aging process can facilitate improved healthspan and potentially lifespan …
The somatotropic axis and aging: benefits of endocrine defects
A Bartke, EO List, JJ Kopchick - Growth Hormone & IGF Research, 2016 - Elsevier
Reduced somatotropic [growth hormone (GH) and insulin-like growth factor-1 (IGF-1)] action
has been associated with delayed and slower aging, reduced risk of frailty, reduced age …
has been associated with delayed and slower aging, reduced risk of frailty, reduced age …