Sex differences in longevity can provide insights into novel mechanisms of aging, yet they
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …

There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

Cellular senescence, a stress-induced irreversible growth arrest often characterized by
expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a …

Ageing causes loss of function in tissues and organs, is accompanied by a chronic
inflammatory process and affects life‐and healthspan. Calorie restriction (CR) is a non …

The increasing ageing of our societies is accompanied by a pandemic of obesity and related
cardiometabolic disorders. Progressive dysfunction of the white adipose tissue is …

The health of an organism is orchestrated by a multitude of molecular and biochemical
networks responsible for ensuring homeostasis within cells and tissues. However, upon …

Dietary restriction (DR), a moderate reduction in food intake, improves health during aging
and extends life span across multiple species. Specific nutrients, rather than overall calories …

This article reviews the main findings that emerged in the intervening years since the
previous volume on hormonal control of growth in the section on the endocrine system of the …

Advancing age is the greatest single risk factor for numerous chronic diseases. Thus, the
ability to target the aging process can facilitate improved healthspan and potentially lifespan …

Reduced somatotropic [growth hormone (GH) and insulin-like growth factor-1 (IGF-1)] action
has been associated with delayed and slower aging, reduced risk of frailty, reduced age …