Advancing the understanding of autism disease mechanisms through genetics
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …
fueled remarkable advances in our understanding of its potential neurobiological …
Effects of cannabis use on human behavior, including cognition, motivation, and psychosis: a review
ND Volkow, JM Swanson, AE Evins, LE DeLisi… - JAMA …, 2016 - jamanetwork.com
With a political debate about the potential risks and benefits of cannabis use as a backdrop,
the wave of legalization and liberalization initiatives continues to spread. Four states …
the wave of legalization and liberalization initiatives continues to spread. Four states …
Schizophrenia risk from complex variation of complement component 4
A Sekar, AR Bialas, H De Rivera, A Davis… - Nature, 2016 - nature.com
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms.
Schizophrenia's strongest genetic association at a population level involves variation in the …
Schizophrenia's strongest genetic association at a population level involves variation in the …
A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression
DR Goldsmith, MH Rapaport, BJ Miller - Molecular psychiatry, 2016 - nature.com
Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been
associated with aberrant blood cytokine levels; however, neither the pattern of cytokine …
associated with aberrant blood cytokine levels; however, neither the pattern of cytokine …
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …
previous genome-wide studies were unable to identify risk loci among individuals of …
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
Autism spectrum disorder (ASD) involves substantial genetic contributions. These
contributions are profoundly heterogeneous but may converge on common pathways that …
contributions are profoundly heterogeneous but may converge on common pathways that …
Developing and evaluating polygenic risk prediction models for stratified disease prevention
Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …
accordance with recent events, such as discoveries of large numbers of disease …
Detection and interpretation of shared genetic influences on 42 human traits
We performed a scan for genetic variants associated with multiple phenotypes by comparing
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 …
Chromosome conformation elucidates regulatory relationships in developing human brain
Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
Mendelian randomization studies are often performed in an instrumental variables
framework, using germline genetic variants as instruments for modifiable disease risk factors …
framework, using germline genetic variants as instruments for modifiable disease risk factors …