Antibody drug conjugates (ADCs) are an emerging class of chemotherapeutic cancer
treatment agents that combine the targeting specificity of antibodies with the efficient cell …

Recent data about structure, interaction with biometals, aggregation state, proteolysis by
angiotensin converting enzyme, neurotoxicity and amyloidogenicity of amyloid-β containing …

Common yet often overlooked, deamidation of peptidyl asparagine (Asn or N) generates
aspartic acid (Asp or D) or isoaspartic acid (isoAsp or isoD). Being a spontaneous, non …

Six ion fragmentation techniques that can distinguish aspartic acid from its isomer,
isoaspartic acid, were compared. MALDI post-source decay (PSD), MALDI 157 nm …

Deamidation of glutamine (Gln) residues is a spontaneous or enzymatic process with
significant implications in aging and human pathology. Although some methods are …

Protein ageing is often mediated by the formation of succinimide intermediates. These short-
lived intermediates derive from asparaginyl deamidation and aspartyl dehydration and are …

Endoplasmic reticulum stress and chaperone dysfunction have recently been associated
with poor prognoses in various cancers. The newly discovered chaperone protein l …

In proteins and peptides, d-aspartic acid (d-Asp) and d-β-Asp residues can be
spontaneously formed via racemization of the succinimide intermediate formed from l-Asp …

Carnivorous plants represent a so far underexploited reservoir of novel proteases with
potentially useful activities. Here we investigate 44 cysteine proteases from the Cape …

Aspartate (Asp) isomerization is a common degradation pathway and a potential critical
quality attribute that needs to be well characterized during the optimization and development …