A perfect storm: impact of genomic variation and serial vaccination on low influenza vaccine effectiveness during the 2014–2015 season

DM Skowronski, C Chambers… - Clinical Infectious …, 2016 - academic.oup.com
Abstract Background. The 2014–2015 influenza season was distinguished by an epidemic
of antigenically-drifted A (H3N2) viruses and vaccine components identical to 2013–2014 …

Meeting report: 4th ISIRV antiviral group conference: novel antiviral therapies for influenza and other respiratory viruses

JL McKimm-Breschkin, AM Fry - Antiviral research, 2016 - Elsevier
Abstract The International Society for Influenza and other Respiratory Virus Diseases (isirv)
held its 4th Antiviral Group Conference at the University of Texas on 2–4 June, 2015. With …

Observational studies and the difficult quest for causality: lessons from vaccine effectiveness and impact studies

M Lipsitch, A Jha, L Simonsen - International journal of …, 2016 - academic.oup.com
Although randomized placebo-controlled trials (RCT) are critical to establish efficacy of
vaccines at the time of licensure, important remaining questions about vaccine effectiveness …

Vaccine-associated enhanced respiratory disease is influenced by haemagglutinin and neuraminidase in whole inactivated influenza virus vaccines

DS Rajão, H Chen, DR Perez… - Journal of general …, 2016 - microbiologyresearch.org
Multiple subtypes and many antigenic variants of influenza A virus (IAV) co-circulate in
swine in the USA, complicating effective use of commercial vaccines to control disease and …

The case test-negative design for studies of the effectiveness of influenza vaccine in inpatient settings

IM Foppa, JM Ferdinands, SS Chaves… - International journal …, 2016 - academic.oup.com
Background: The test-negative design (TND) to evaluate influenza vaccine effectiveness is
based on patients seeking care for acute respiratory infection, with those who test positive …

A structural and mathematical modeling analysis of the likelihood of antibody-dependent enhancement in influenza

B Ramakrishnan, K Viswanathan, K Tharakaraman… - Trends in …, 2016 - cell.com
Broadly neutralizing monoclonal antibodies (bNAbs) for viral infections, such as HIV,
respiratory syncytial virus (RSV), and influenza, are increasingly entering clinical …

[HTML][HTML] Non-neutralizing antibodies induced by seasonal influenza vaccine prevent, not exacerbate A (H1N1) pdm09 disease

JH Kim, AJ Reber, A Kumar, P Ramos, G Sica… - Scientific Reports, 2016 - nature.com
The association of seasonal trivalent influenza vaccine (TIV) with increased infection by
2009 pandemic H1N1 (A (H1N1) pdm09) virus, initially observed in Canada, has elicited …

[HTML][HTML] Pandemic vaccination strategies and influenza severe outcomes during the influenza A (H1N1) pdm09 pandemic and the post-pandemic influenza season …

JG Cuesta, P Aavitsland, H Englund… - …, 2016 - eurosurveillance.org
During the 2009/10 influenza A (H1N1) pdm09 pandemic, the five Nordic countries adopted
different approaches to pandemic vaccination. We compared pandemic vaccination …

[HTML][HTML] Infant respiratory outcomes associated with prenatal exposure to maternal 2009 A/H1N1 influenza vaccination

DB Fell, K Wilson, R Ducharme, S Hawken… - PLoS …, 2016 - journals.plos.org
Background Infants are at high risk for influenza illness, but are ineligible for vaccination
before 6 months. Transfer of maternal antibodies to the fetus has been demonstrated for …

[HTML][HTML] Efficacy of a trivalent influenza vaccine against seasonal strains and against 2009 pandemic H1N1: A randomized, placebo-controlled trial

WJH Mcbride, WP Abhayaratna, I Barr, R Booy… - Vaccine, 2016 - Elsevier
Abstract Background Before pandemic H1N1 vaccines were available, the potential benefit
of existing seasonal trivalent inactivated influenza vaccines (IIV3s) against influenza due to …