The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions
such as hypertension and valve disease. The pathophysiology of hypertrophy is complex …

Accumulating evidence reveals involvement of T lymphocytes and adaptive immunity in the
chronic inflammation associated with infectious and noninfectious diseases of the heart …

An increase in mechanical load in the heart causes cardiac hypertrophy, either
physiologically (heart development, exercise and pregnancy) or pathologically (high blood …

Aims TGF-β regulates tissue fibrosis: TGF-β promotes fibrosis, whereas bone morphogenetic
protein (BMP)-7 is antifibrotic. To demonstrate that (i) left ventricular (LV) remodelling after …

Sodium phenylbutyrate (PBA) has been reported to inhibit endoplasmic reticulum stress and
histone deacetylation (HDAC), both of which are novel therapeutic targets for cardiac …

Recent systems biological studies of cardiac systems have greatly advanced our
understanding of cardiac physiology with a particular focus on the excitation-contraction …

目的研究穿心莲内酯对心肌肥厚大鼠心肌胶原及心肌酶谱的影响. 方法健康雄性SD
大鼠随机分为对照组, 心肌肥厚模型组, 溶剂对照组, 低剂量, 高剂量穿心莲内酯组. 采用连续10 …

As the population ages, the prevalence of diastolic dysfunction and heart failure with
preserved ejection fraction is rising. The presentation and management of these patients is …

MikroRNA (miRNA)'lar kardiyak gelişmeyi, hipertrofiyi ve anjiogenezi düzenlemektedir.
miRNA'lar gen ekspresyonunun düzenlenmesinde hedef mRNA'nın ya degredasyonunu …