Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS
P Ziltener, T Reinheckel, A Oxenius - PLoS pathogens, 2016 - journals.plos.org
Legionella pneumophila is a facultative intracellular bacterium that lives in aquatic
environments where it parasitizes amoeba. However, upon inhalation of contaminated …
environments where it parasitizes amoeba. However, upon inhalation of contaminated …
Space: a final frontier for vacuolar pathogens
There is a fundamental gap in our understanding of how a eukaryotic cell apportions the
limited space within its cell membrane. Upon infection, a cell competes with intracellular …
limited space within its cell membrane. Upon infection, a cell competes with intracellular …
Inflammasome Recognition and Regulation of the Legionella Flagellum
U Schell, S Simon, H Hilbi - Inflammasome Signaling and Bacterial …, 2016 - Springer
Abstract The Gram-negative bacterium Legionella pneumophila colonizes extracellular
environmental niches and infects free-living protozoa. Upon inhalation into the human lung …
environmental niches and infects free-living protozoa. Upon inhalation into the human lung …
Pathway analysis using 13C‐glycerol and other carbon tracers reveals a bipartite metabolism of Legionella pneumophila
I Häuslein, C Manske, W Goebel… - Molecular …, 2016 - Wiley Online Library
Amino acids represent the prime carbon and energy source for Legionella pneumophila, a
facultative intracellular pathogen, which can cause a life‐threatening pneumonia termed …
facultative intracellular pathogen, which can cause a life‐threatening pneumonia termed …
The Legionella pneumophila CpxRA two‐component regulatory system: new insights into CpxR's function as a dual regulator and its connection to the effectors …
YS Feldheim, T Zusman, Y Speiser… - Molecular …, 2016 - Wiley Online Library
Legionella pneumophila utilizes the Icm/Dot type‐IV secretion system to translocate
approximately 300 effector proteins into host cells, and the CpxRA two‐component system …
approximately 300 effector proteins into host cells, and the CpxRA two‐component system …
Legionella pneumophila prevents proliferation of its natural host Acanthamoeba castellanii
L Mengue, M Régnacq, W Aucher, E Portier… - Scientific reports, 2016 - nature.com
Legionella pneumophila is a ubiquitous, pathogenic, Gram-negative bacterium responsible
for legionellosis. Like many other amoeba-resistant microorganisms, L. pneumophila resists …
for legionellosis. Like many other amoeba-resistant microorganisms, L. pneumophila resists …
In silico driven design and synthesis of rhodanine derivatives as novel antibacterials targeting the enoyl reductase InhA
L Slepikas, G Chiriano, R Perozzo… - Journal of medicinal …, 2016 - ACS Publications
Here, we report on the design, synthesis, and biological evaluation of 4-thiazolidinone
(rhodanine) derivatives targeting Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier …
(rhodanine) derivatives targeting Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier …
The α‐hydroxyketone LAI‐1 regulates motility, Lqs‐dependent phosphorylation signalling and gene expression of Legionella pneumophila
U Schell, S Simon, T Sahr, D Hager… - Molecular …, 2016 - Wiley Online Library
The causative agent of Legionnaires' disease, L egionella pneumophila, employs the
autoinducer compound LAI‐1 (3‐hydroxypentadecane‐4‐one) for cell–cell communication …
autoinducer compound LAI‐1 (3‐hydroxypentadecane‐4‐one) for cell–cell communication …
Metabolism of myo-Inositol by Legionella pneumophila Promotes Infection of Amoebae and Macrophages
C Manske, U Schell, H Hilbi - Applied and environmental …, 2016 - Am Soc Microbiol
Legionella pneumophila is a natural parasite of environmental amoebae and the causative
agent of a severe pneumonia termed Legionnaires' disease. The facultative intracellular …
agent of a severe pneumonia termed Legionnaires' disease. The facultative intracellular …
Regulatory circuits involved in Legionella pneumophila virulence: the role of Hfq and the cis-encoded sRNA Anti-hfq
G Oliva - 2016 - theses.hal.science
Legionella pneumophila, the causative agent of the pneumonia-like Legionnaires' disease,
is commonly found in aquatic habitats worldwide where it multiplies within protozoa. To …
is commonly found in aquatic habitats worldwide where it multiplies within protozoa. To …