Tumor progression toward malignancy often requires a metabolic rewiring of cancer cells to
meet changes in metabolic demand to forefront nutrient and oxygen withdrawal, together …

Purpose The tumor–stroma interaction is critical for the development and progression of
cancer. Cancer-associated fibroblasts (CAFs), one of the major components of the tumor …

The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of
pancreatic ductal adenocarcinoma (PDA), and specific conditions in the stroma may …

The tumor microenvironment has an essential role in defining tumor malignancy, since it can
either promote or prevent tumor initiation and subsequent progression and metastatic …

Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), have emerged as
a major form of intercellular communication, playing important roles in several physiological …

The discovery that tumor cells are able to switch to intensive glycolysis even under
conditions of adequate oxygen by Otto Warburg pioneered in the field of cancer biology …

Tumor cells exhibit metabolic reprogramming according to microenvironmental scenarios (ie
stroma composition and/or anticancer drugs burden) to meet their demands for energy, rapid …