Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures
Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …
optimize behavior and physiology in humans. Relatively recent changes to our …
Genetic markers of type 2 diabetes: Progress in genome‐wide association studies and clinical application for risk prediction: 2 型糖尿病的遗传标记: 风险预测的全 …
X Wang, G Strizich, Y Hu, T Wang… - Journal of …, 2016 - Wiley Online Library
摘要2 型糖尿病已经成为全球公共卫生的主要挑战. 迄今为止, 通过全基因组关联研究(genome‐
wide association studies, GWAS) 总共已经鉴定出了83 个2 型糖尿病易感位点. 为了发现2 …
wide association studies, GWAS) 总共已经鉴定出了83 个2 型糖尿病易感位点. 为了发现2 …
[HTML][HTML] Colocalization of GWAS and eQTL signals detects target genes
The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding
regions of the genome. One possible hypothesis is that these GWAS risk loci alter the …
regions of the genome. One possible hypothesis is that these GWAS risk loci alter the …
[HTML][HTML] Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …
[HTML][HTML] Fatty acid desaturases, polyunsaturated fatty acid regulation, and biotechnological advances
JM Lee, H Lee, SB Kang, WJ Park - Nutrients, 2016 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human
health and development, and numerous fatty acid desaturases play key roles in synthesizing …
health and development, and numerous fatty acid desaturases play key roles in synthesizing …
[HTML][HTML] Contrasting the genetic architecture of 30 complex traits from summary association data
Variance-component methods that estimate the aggregate contribution of large sets of
variants to the heritability of complex traits have yielded important insights into the genetic …
variants to the heritability of complex traits have yielded important insights into the genetic …
[HTML][HTML] Genetics of insulin resistance and the metabolic syndrome
AE Brown, M Walker - Current cardiology reports, 2016 - Springer
Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …
factors for the development of cardiovascular disease. They result from the interplay of …
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies
DI Swerdlow, KB Kuchenbaecker… - International journal …, 2016 - academic.oup.com
Mendelian randomization (MR) studies typically assess the pathogenic relevance of
environmental exposures or disease biomarkers, using genetic variants that instrument …
environmental exposures or disease biomarkers, using genetic variants that instrument …
Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
Mapping perturbed molecular circuits that underlie complex diseases remains a great
challenge. We developed a comprehensive resource of 394 cell type–and tissue-specific …
challenge. We developed a comprehensive resource of 394 cell type–and tissue-specific …