Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Lipopolysaccharides (LPS) of Gram negative bacteria are one of the most potent stimulators
of the host innate immune system and LPS recognition is essential for the host organism to …

Many immunostimulants act as vaccine adjuvants via activation of the innate immune
system, although in many cases it is unclear which specific molecules contribute to the …

Inhalation of the bacterium Yersinia pestis results in primary pneumonic plague. Pneumonic
plague is the most severe manifestation of plague, with mortality rates approaching 100% in …

Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-
negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling …

Lipid A is the lipid anchor of a lipopolysaccharide in the outer leaflet of the outer membrane
of Gram-negative bacteria. In general, lipid A consists of two phosphorylated N-acetyl …

Plague is one of the world's most lethal human diseases caused by Yersinia pestis, a Gram-
negative bacterium. Despite overwhelming studies for many years worldwide, there is no …

Pathogens have evolved to complete the virulence cycle of colonization, replication and
dissemination in intimate association with a complex network of extracellular and …

Innate immunity plays a central role in resolving infections by pathogens. Host survival
during plague, caused by the Gram-negative bacterium Yersinia pestis, is favored by a …

Diabetes is associated with increased susceptibility to Klebsiella pneumoniae and poor
prognosis with infection. We demonstrate accelerated mortality in mice with streptozotocin …